Advanced Liver-Biliary Pancreatic & Surgical Clinic
Liver Transplant in Singapore
Liver Transplant in Singapore — Life-Saving Care with Surgical Excellence
Liver transplantation is a surgical procedure in which a diseased or failing liver is replaced with a healthy liver from a donor. It is typically recommended for individuals with end-stage liver disease, acute liver failure, or certain liver cancers when other treatments are no longer effective.
Integrative Care for Liver Transplantation
Liver diseases often progress silently, and many individuals only notice symptoms when the damage has become severe. When the liver can no longer function properly, a transplant may be the most effective solution. At ALPS Clinic, our experienced Singapore liver surgeon provides advanced evaluation for conditions such as cirrhosis, acute liver failure, and hepatocellular carcinoma. Our goal is to ensure timely treatment that restores liver function and supports long-term health.
Indications for Liver Transplantation
Liver transplantation is a life-saving procedure for patients with irreversible liver disease or liver-related complications. Traditional indications include:
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End-stage liver disease (cirrhosis with complications)
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Acute liver failure
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Hepatocellular carcinoma (meeting Milan/UCSF criteria)
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Autoimmune liver diseases (e.g., primary sclerosing cholangitis, primary biliary cholangitis
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Metabolic liver disorders (e.g., Wilson’s disease, Alpha-1 Antitrypsin Deficiency)
Newer Indications for Liver Transplantation
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Cholangiocarcinoma (selected cases) – Patients following neoadjuvant therapy.
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Hepatic Epithelioid Hemangioendothelioma (HEHE) – Rare liver vascular tumors.
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Neuroendocrine Liver Metastases (NELM) – Highly selected cases with liver-only disease.
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Colorectal Liver Metastases (Experimental cases) – Undergoing clinical trials.
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Acute-on-Chronic Liver Failure (ACLF) – An emerging indication for transplantation.
Types of Liver Transplantation
Deceased Donor Liver Transplant (DDLT) ( Restricted only to public sector hospitals) The liver is obtained from a brain-dead donor. Can be performed as:
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Whole liver transplant – The entire liver is transplanted.
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Split liver transplant – The liver is divided and used for two recipients (usually an adult and a child).
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Living Donor Liver Transplant (LDLT)\ A portion of the liver is transplanted from a living donor to the recipient Types of LDLT:
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Right lobe liver transplant – More commonly used for adult recipients.
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Left lobe liver transplant – Often used for children or small adults.
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Left lateral segment transplant – Used mainly for pediatric recipients.
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Extended right lobe transplant – Includes the right lobe with middle hepatic vein
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Auxiliary Liver Transplantation
A portion of a healthy liver is transplanted, while the recipient’s diseased liver remains. Used for acute liver failure where liver regeneration is expected. Variants:-
Auxiliary Partial Orthotopic Liver Transplantation (APOLT) – Part of the donor liver supports the recipient’s native liver.
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Heterotopic Auxiliary Liver Transplant – The donor liver is placed in another location, keeping the native liver.
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Special types of Liver Transplantation
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ABO-Incompatible Liver Transplantation
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Liver transplant between incompatible blood groups.
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Requires special treatments (e.g., plasmapheresis, rituximab) to prevent rejection.
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​Dual Graft Liver Transplantation
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Two partial liver grafts (from two living donors or one living and one deceased donor) are used for a single recipient.
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Performed when one donor graft is too small for the recipient.
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Auxiliary Partial Liver Transplant for Metabolic Disorders
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Used for genetic liver diseases (e.g., urea cycle disorders).
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Provides functional donor liver while preserving part of the native liver ​ ​
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Liver Transplant Variants in Specific Conditions
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Liver Transplant for Hepatocellular Carcinoma (HCC)
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Used in patients meeting Milan or UCSF criteria.
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Can be performed with bridging therapies before transplant.
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Liver Transplant for Acute Liver Failure
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Emergency liver transplantation in patients with fulminant liver failure.
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Liver Transplant for Metabolic
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Liver Diseases Used in conditions like Wilson’s disease,
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Crigler-Najjar syndrome, and urea cycle disorders.
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Liver Transplant for Cholestatic Liver Diseases
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Used in primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and biliary atresia.
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Severe Polycystic Liver disease
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Liver Transplant for Emerging Indications
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Colorectal Liver
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Hilar cholangiocarcinoma (Bile duct cancer)
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Hepatic Epithelioid Hemangioendothelioma (HEHE)
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Neuroendocrine Liver Metastases (NELM)
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Fibrolamellar Hepatocellular Carcinoma (FLC)
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Cystic Liver Tumors Hepatoblastoma (Children)
Why Choose ALPS Clinic for Laparoscopic Living Donor Liver Transplant in Singapore?
Choosing ALPS Clinic means receiving advanced surgical expertise supported by personalised, compassionate care. We focus on protecting donor safety while helping recipients achieve a healthier future.
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Expert Surgical Leadership
Our trained Singapore liver surgeon performs laparoscopic living donor procedures, prioritising safety and comfort for every patient.
Laparoscopic Technology
Modern surgical systems enhance precision, minimize complications, and facilitate faster healing.
End-to-End Transplant Care
Patients and donors experience a comprehensive liver transplant Singapore, from thorough evaluation to dedicated post-operative follow-up.
Outcomes & Trust
Proven results in complex cases provide reassurance and clear guidance when understanding liver transplant cost in Singapore.
